Some of the drugs referred to as club drugs are ketamine, MDMA, GHB Clonazepam is a Rohypnol-type drug that is being used in sexual assaults. The San.
In June 2000, a 17-year-old high school student in Bakersfield, California, overdosed on butanediol after he drank water into which he had mixed a dose of the drug. He blacked out and was taken to a hospital. His heart rate dropped to 30 beats per minute and his breathing to 6 to 8 times a minute. (A normal heart rate is 75 to 100 beats per minute while normal respiration is 16 to 20 per minute.) According to paramedics, drugs normally used to jump-start the heart after an overdose of narcotics such as heroin cannot counteract the effects of GHB or butanediol; paramedics can only provide an airway, do cardiopulmonary resuscitation, and maintain basic life functions until the drug wears off.
Xanax and Klonopin are the respective trademark names for alprazolam and clonazepam, two medications that belong to the benzodiazepine class of drugs.
Mixing drugs is never recommended, yet interactions between benzos and harder substances can all depend on the drugs in question. When it comes to hallucinogens like LSD, benzos can work to alleviate some of the stress associated with bad trips. The sedative nature of benzos can also alleviate symptoms that typically occur during methamphetamine comedowns, such as irritability and insomnia.
Side effects of Xanax may include rashes, drowsiness, constipation, slurred speech and respiratory depression.
Each of these drugs is evaluated according to the NIOSH criteria for a hazardous drug. In April 2009, the FDA issued a new warning on clonazepam based on.
The following information was available in the drug package insert (319 KB PDF) :
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"Animal Findings: In three studies in which Klonopin was administered orally to pregnant rabbits at doses of 0.2, 1, 5 or 10 mg/kg/day (low dose approximay 0.2 times the maximum recommended human dose of 20 mg/day for seizure disorders and equivalent to the maximum dose of 4 mg/day for panic disorder, on a mg/m2 basis) during the period of organogenesis, a similar pattern of malformations (cleft palate, open eyelid, fused sternebrae and limb defects) was observed in a low, non-dose-related incidence in exposed litters from all dosage groups.
Pharmacokinetics of the anticonvulsant drug clonazepam evaluated from single oral and intravenous doses and by repeated oral administration.
March 1975, Volume 9, Issue 2, pp 155-159 First online:
Eight healthy volunteers were given single i.v. and oral doses of clonazepam (2 mg). The disposition curves after i.v. administration showed a biexponential decline and the data were applied to a two-compartment open model. The volume of distribution ((V d )β) ranged between 1.5 and 4.4 l/kg and the plasma half-life (t 1/2 ) between 19 and 60 hours. Absorption after oral administration was fast, with peak plasma concentrations within 4 hours in all subjects. Five of the subjects received repeated oral doses of clonazepam 0.5 mg bid for 15 days. The plasma level during steady state (estimated as C min within the dose interval) could be predicted from the constants A, B, α and β obtained in the single dose study with a coefficient of variation of 6%. The plasma half-lives after cessation of the subchronic dosing were of the same magnitude as after single doses.
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European Journal of Clinical Pharmacology.
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Clonazepam: Generic equivalent of Klonopin. New approved drug details including side effects, uses and general information.
It is the generic equivalent of Roche Laboratories' Klonopin. Clonazepam has been approved as an anticonvulsant to be manufactured in 0.5mg, 1mg and 2mg tablets.
Neurology Family Medicine Genetic Disease Seizure Disorders.
Company: Watson Pharmaceuticals Approval Status: Approved January 1998 Specific Treatments: anticonvulsant Therapeutic Areas.